Overview
IV ketamine infusion for depression is a specialist treatment that may be considered for some people with persistent depressive symptoms. It is typically discussed when standard approaches have not provided sufficient improvement. Treatment is delivered in a controlled clinical setting with medical monitoring and a structured follow up plan.
Ketamine has been used safely in medicine for many years. In carefully controlled low doses, IV ketamine infusion for depression may influence nervous system pathways involved in mood regulation and symptom persistence. Some people experience a change in mood within hours or days, although response varies and benefits may be time limited without an ongoing care plan.
A consultant led assessment is required to confirm suitability, discuss potential risks, and ensure that IV ketamine infusion is integrated into a wider treatment strategy.
Who this treatment helps
IV ketamine infusion for depression may be considered for people with:
- Persistent depression not improving with standard treatments
- Symptoms significantly affecting daily function, sleep, or motivation
- Difficulty engaging with therapy or rehabilitation because of symptom severity
- Co existing chronic pain or nerve sensitivity in some cases
- A need for a carefully monitored specialist option after consultant assessment
Suitability depends on medical history, medications, physical health, and mental health risk factors. Your consultant will explain whether this treatment is appropriate for your situation.
What is an IV ketamine infusion
An IV ketamine infusion involves delivering a controlled low dose of ketamine through a drip into a vein over a set period of time. The aim is to influence pathways in the nervous system that are involved in mood regulation.
The infusion takes place with clinical monitoring throughout. This usually includes monitoring of blood pressure, heart rate, and oxygen levels. The dose and duration are tailored to the individual based on clinical assessment and response.
IV ketamine infusion for depression is normally used as part of a broader care plan. It is not a standalone cure and tends to work best when combined with psychological support, medication review, and structured recovery strategies.
What to expect during the procedure
Your treatment visit typically includes several stages to ensure safety and comfort.
- Pre infusion clinical review to confirm you are well enough to proceed
- Baseline observations and monitoring setup
- Placement of a small cannula into a vein in the arm or hand
- The infusion delivered gradually over the planned time period
- Continuous staff monitoring during the infusion
- A short observation period after the infusion before discharge
You may be advised to arrange transport home and avoid driving on the day of treatment.
After the procedure
After IV ketamine infusion for depression, some temporary effects may occur.
- Tiredness or drowsiness
- Lightheadedness or nausea
- Temporary changes in perception during the infusion which usually settle afterwards
- Mood changes that may occur within hours or over the following days
Your consultant may recommend:
- Rest for the remainder of the day
- Avoid driving, alcohol, or important decisions for 24 hours
- Keeping a brief record of mood, sleep, and energy changes
- Attending follow up appointments to review treatment response
If a course of infusions is recommended, the schedule will be clearly explained and adjusted according to your response.
Benefits
Potential benefits of IV ketamine infusion for depression may include:
- Reduction in depressive symptoms for selected patients
- Possible improvement in motivation, sleep, or daily function
- A monitored specialist option when other treatments have not helped
- Support for engagement with therapy or lifestyle based recovery
- Possible benefit for some people with co existing neuropathic pain
Benefits vary between individuals and are always considered alongside safety and suitability.
Possible risks and side effects
IV ketamine infusions are delivered in a monitored clinical environment to reduce risk, but side effects may occur.
- Temporary increase in blood pressure or heart rate
- Nausea or dizziness
- Headache
- Drowsiness or fatigue
- Transient anxiety or agitation
- Temporary perceptual changes or dissociation during infusion
- Rare allergic reaction or cardiovascular complications
Your consultant will explain the potential risks and ensure appropriate safety screening before treatment.
When to consider other options
IV ketamine infusion may not be appropriate in all cases. Alternative approaches may be discussed if:
- Depression may respond better to medication adjustment or structured therapy
- Certain medical conditions increase treatment risk
- There are psychiatric or substance related concerns
- There is no support plan for ongoing care
Other options may include medication optimisation, structured psychological therapy such as CBT or ACT, multidisciplinary support, sleep interventions, or coordinated psychiatric care.
Safety note
Please inform your consultant about all medications, allergies, and medical conditions. This includes heart or blood pressure conditions, liver problems, glaucoma, seizure history, pregnancy, or previous reactions to anaesthetic medications. You should arrange transport home as you may not be able to drive after treatment.
Arrange a consultation to discuss whether IV ketamine infusion for depression may be appropriate and how it could fit within your wider treatment plan.
You can also explore our chronic depression treatment, view all pain treatments, or learn more about our specialist services.